Taking the Temperature on Platelet Storage

An Overview on Platelet-derived Microparticles in Platelet Concentrates: blood collection, method preparation and storage

Preparations of platelet concentrates (PCs) that are stored under blood bank conditions and used for transfusion purposes, appear to be enriched in platelet derived-microparticles (PMPs) with high coagulant activity that may change platelet efficacy and safety issues. High shear stress could cause shedding of PMPs from the platelet plasma membrane, platelet aggregation, and activation of the co...

Enhanced shear-induced platelet aggregation due to low-temperature storage.

BACKGROUND Refrigeration of platelets (PLTs) offers an attractive alternative to the currently practiced storage at room temperature since it may mitigate problems associated with bacterial contamination and extend storage lifetime. Refrigeration causes a number of biophysical and biochemical changes in PLTs and decreases PLT circulation time in vivo. However, the effect of refrigeration on PLT...

Taking the temperature.

of nicked DNA substrates. This finding could be of therapeutic importance. Dideoxynucleoside drugs and their analogues — such as ddC, ddI, AZT, D4T and T3C — are not usually incorporated into genomic DNA in large amounts. But they do get into our genome through the action of polymerase b, which can incorporate them into repair patches during base excision repair 8 , and through another polymera...

The effect of platelet concentrate storage temperature on adenine nucleotide metabolism.

The effect of platelet concentrate storage temperature (4 degrees C versus 22 degrees C) on platelet adenine nucleotide metabolism was studied. In general, levels of platelet ATP and ADP, the release reaction, and the metabolis nucleotide pool were best preserved for 72 hr by storage of concentrates at 4 degrees C. Storage of concentrates for 72 hr at 22 degrees C was occasionally associated wi...

Efffect of storage temperature and container type on storage and shelf life of persimmon fruits